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In 1979, a group of scientists from the Mangosteen Research Development Centre successfully identified and extracted a substance from the mangosteen peel called GM-1 (the most active xanthone).




GM-1 is found to be:

  • Effective in killing bacteria that are Antibiotic-resistant.
  • Three times more effective against inflammation than Aspirin.
  • A better antioxidant quality than vitamin E.
  • Highly effective in killing Cancer cells.


GM-1 has 4-A Properties:

  • Anti-Bacterial
  • Anti-Inflammatory
  • Anti-Oxidant
  • Anti-Cancer 



GM-1 and the effects against Cancer



Xanthones are natural substances found in the Genus Garcinia, particularly in mangosteen. 

Scientific studies, particularly by the scientists of the Thai Mangosteen Research and Development Center (TMRDC) at Asian Phytoceuticals Public Company Limited (APCO) have established the following activities of xanthones : 

1. Growth inhibition and the ability to kill antibiotic-resistant gram-positive bacteria, the effectiveness equals that of vancomycin.

2. Anti-inflammatory, 3 times as effective as aspirin.

3. Analgesic (pain relieving) and anti-allergy.

4. Anti-oxidant - preventing heart diseases from LDL cholesterol oxidation.

5. Kills breast cancer cells, leukemia cells, liver cancer cells, kidney cancer cells, stomach/intestinal cancer cells, and lung cancer cells (based on laboratory testing).

6. Kill tuberculosis bacterium (based on laboratory testing).

7. Inhibit the propagation of HIV (based on laboratory testing).

8. Increase the phagocytosis, the cellular process of eliminating foreign matters and bacteria.

9. Inhibit cartilage deterioration and increase bone mass (based on laboratory testing)


GM-1 is found, by scientists at TMRDC, to be the most active amongst 41 xanthones in mangosteen. 


1. J. Nat.Prod. 1987 May-June 50(3) 474-8.

2. J. Sci. Soc. Thailand, 12(1986) 239-242.

3. Free Radic Res. 2000 Nov;33(5):643-59.

4. Planta Med. 1996 Aug;62(4):381-2

5. Free Radic Res. 1995 Aug;23(2):175-84.

6. J Pharmacol Sci. 2004 May;95(1):33-40.

7. J Med Assoc Thai. 1997 Sep;80 Suppl 1:S149-54.

8. Chem Pharm Bull(Tokyo) 2003 Jul; 51(7):857-9.

9. M.Sc. in Pharmacology Thesis, Chiang Mai University 1998. (Ajchara Chaikaeo)

10. M.Sc. in Organic Chemistry Thesis, Prince of Songkla University 1985.

(Wilawan Mahabusarakam) 


Because of the broad spectrum of pharmacological activities, mangosteen juice containing xanthones have been used, particularly in the United States, to increase the body ability to cope with pain, fever, inflammation, diarrhea, bacterial and viral infection, atherosclerosis, aging, arthritis, mouth ulcer, intestinal ulcer, stomach ulcer and cancer.


To obtain a more efficacious formulation than the ordinary mangosteen juice, GM-1 in the capsules is mixed with its synergistic herbal extracts.


In the latest studies, scientists at TMRDC have found significant results which shed light on how GM-1 acts on the body system, modulate the immunity and is responsible for the wide spectrum of activities. This led us to believe that GM-1 will help the body to cope not only with the aforementioned physical complaints, but also with Alzheimer, diabetes, osteoporosis, depression and anxiety, Parkinson's disease, cataract and glaucoma, vertigo, high blood pressure and other auto-immune related diseases. 


Watch Video of Prof. Dr. Pichaet Wiriyachitra on Th17 Regimen



Mangosteen Products: From the Lab Bench to the World Market


Professor Dr. Pichaet Wiriyachitra

Mangosteen Research and Development Center,

Asian Phytoceuticals Public Co., Ltd.

Ratchadaphisek Road, Bangkok, THAILAND


Both in Thailand and other countries, people with skin problems, psoriasis, gastro-intestinal ulcers, arthritis, diabetes, allergy, hyper-thyroid, liver damage, kidney damage, cancer, aids, high blood pressure and Parkinson’s disease have successfully alleviated their symptoms by using mangosteen-derived products. These products, developed from the findings of researchers of Thai Mangosteen Research and Development Center (MRDC), are cosmetics containing GM-1 from mangosteen, the dietary supplement containing


synergistic mixture of GM-1 and refined food extracts, and the mangosteen essence with standardised content of GM-1 but without the rind material that may be contaminated with insecticides and liver-toxic content of dark brown tannins.


The success in developing these popular, widely-appreciated as safe and efficacious products results from the application of scientific findings of the researchers from MRDC in conjunction with innovative marketing techniques.


This presentation will describe the pathway of product development, starting from its beginning in 1977. The impression of volunteers and consumers who have used these products will be presented together with the modes of actions, particularly the immuno-modulating activities, that are responsible for the corresponding efficacy.